Robotic Aseptic Processing: Utility in the Filling of Syringes, Cartridges and Ready-to-Use Vials

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Not long ago, robots focused on terminal functions in the pharmaceutical industry, such as palletizing and packaging boxes.

Robot integration is currently being developed in the main packaging process of RTU containers, such as

, Vials and cartridges. Therefore, the only step left in the process is to fill and complete the container, which eliminates most process difficulties, and the packaging is pre-prepared in the RTU system.

Robotic solutions provide pharmaceutical manufacturers with a faster, more cost-effective and flexible way to fill different container formats through the same filling platform, thereby satisfying the need for customized packaging, small batches, rapid format and product conversion and more The growing demand for fewer users to intervene in the filling process.

Conventional systems do not meet the requirements of multiple formats, small batch flexibility or reduced risk size and repeatable processes. Advances in technology make robotics compatible with aseptic production, with complete tolerance to fungicides, and almost no particles are produced.

Robots provide flexibility, which is an advantage over traditional aseptic machinery. If the application or container format is changed and fully adapted, they can be reprogrammed with minimal investment.

Vials, syringes and

The supplied products have been aseptically cleaned and can be used in closed nests/buckets, so there is no need for disinfection, cleaning or special transportation. Place the nest with empty containers in an ISO standard barrel so that it can be transported safely and avoid any contact between glass and glass.

The user transports the nest/hopper to its containment area (RABS/isolator), where it can be automatically bagged and transferred to the next location. During the shelling process, the manipulator will carefully remove the preheated lid, which will be discharged through the mouse hole in the substrate of the restricted access barrier system (RABS)/isolator chamber into the waste container.

Now, the container in the nest is only exposed to the surrounding environment, which is common in isolators or RAB enclosures, thereby minimizing the risk of potential contamination.

Thanks to the RABS/isolator, the robotic arm provides clean and safe operation in a sterile environment, avoiding any potential contamination caused by human intervention during the removal and transfer of the lid.

After releasing the container in the nest/bucket from the top, it advances to the next step, so that the second robotic arm moves the nest with empty containers to the filling position.

The filling head has a fixed position throughout the filling process. The robot transfers and nests the containers to the filling position of each container. This greatly reduces any risk of particle generation and contamination.

By placing appropriate closure elements immediately after filling each container, the stopper operation is performed in a synchronized manner; using this method can minimize the exposure of the filled container to the environment.

The robotic arm replaces the sleeve to the original position in the barrel for the next technical process. After all the containers that make up the nest are filled and stuffed.

When carefully handling nests and vials, it is essential to reduce particle generation, accidental vial shaking, and air interference. At the same time, the robot is automatically integrated into the filling line process to provide reliable action repeatability.

This helps prevent leaks and other incidents that would otherwise lead to unplanned manual intervention and possibly endanger the sterile environment. SP covers all ranges of aseptic processing methods and tools, from stability testing, cycle development, pilot and clinical batch production to complete aseptic production and commercial production batches.

This

It is a multifunctional robotic filling and stopper/stopper machine for nested plastic and glass syringes, vials and cartridges.

It can process up to 200 units per minute and up to 10 nozzles, and the system can include IPC statistical inspection weighing units. It also provides a complete production line solution with lid removal, thick line removal, labeling machine, paste removal knife and rod inserter. Clean room robots are used to place syringes for filling and stoppers, and can be used for VHP cleaning options.

It is jointly produced by well-known, well-known and highly respected scientific instrument brands (SP VirTis, SP FTS, SP Hotpack, SP Hull, SP Genevac, SP PennTech and most recently SP i-Dositecno). It has the largest and most experienced company in freeze drying/freeze drying, complete aseptic filling production line, centrifugal evaporation and concentration, temperature control/thermal management, glassware washing machine and controlled environment.

SP is a part of SP Industries, Inc. SP Industries is a leading designer and manufacturer of the most advanced laboratory equipment, pharmaceutical manufacturing solutions, laboratory consumables and instruments, and specialty glassware. SP's products support research and production across end-user markets, including pharmaceuticals, scientific research, industry, aerospace, semiconductors, and healthcare. In December 2015, SP Industries was acquired by Port Group (a private investment company established in 1976). The Port Group is a privately held company headquartered in St. Louis, Missouri, focused on operations. SP is headquartered in Warminster, Pennsylvania, with production plants in the United States, Spain and the United Kingdom in Europe, and provides a global sales and service network, and provides comprehensive product support including training and technical support.

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Last updated: 2020, at 10:50 on December 15 am

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